SUPPLEMENT FACTS

Serving size 1 tablet

Thiamin (B-1 as Thiamin Mononitrate) 50 mg

Riboflavin (B-2) 50 mg

Niacin (B-3 as Niacinamide) 50 mg

Vitamin B-6 (as Pyridoxine Hydrochloride) 50 mg

Folic acid 400 mcg

Vitamin B-12 (as Cyanocobalamin) 50 mcg

Biotin (as d-Biotin) 50 mcg

Pantothenic Acid (as d-Calcium Pantothenate and Pantethine) 55 mg

Magnesium (as Magnesium Citrate) 24 mg

Choline (as Choline Bitartrate) 21 mg

Soy Lecithin 50 mg

Inositol 50 mg

Pyridoxal-5-Phosphate 5 mg

Riboflavin-5-Phosphate 5 mg

Other Ingredients: Cellulose (plant origin). Contains <2% of Cellulose coating, Dicalcium Phosphate, Mannitol, Silica, Vegetable Magnesium Stearate.

Free of: artificial color, artificial flavor, preservatives, sugar, starch, milk, lactose, gluten, wheat, yeast, fish, sodium

PRODUCT DISCUSSION

These tablets provide a unique combination of B-Complex vitamins along with their biologically active coenzyme forms for optimal absorption and utilization of nutrients.* The B vitamins play a role in energy metabolism in the body.* Choline and Inositol are essential components of cell membranes.*

STRUCTURE AND FUNCTION

Thiamine (B-1) functions as the coenzyme thiamin pyrophosphate, assisting in the metabolism of carbohydrates and branched-chain amino acids, as well as in production of the neurotransmitter acetylcholine.*

Riboflavin (B-2) assists in oxidation/reduction reactions, including those involved in energy pathways and the metabolism of carbohydrates, fats and proteins.* It also helps maintain the skin and mucous membranes, the cornea of the eye, and nerve sheaths.*

Niacin (B-3), also known as nicotinic acid and nicotinamide, serves as a coenzyme in oxidation/reduction reactions as nicotinamide adenine dinucleotide (NAD) and its phosphate form (NADP). NAD functions in intracellular respiration and oxidation of glyceraldehydes, lactate, alcohol, and other fuel molecules. NADP is required in reductive biosyntheses, such as fatty acid and steroid synthesis. Niacin is needed for the metabolism of food, maintenance of healthy skin and nerve cells, DNA replication and repair, and cell differentiation.*

The major coenzyme forms of Pyridoxine (B-6) are pyridoxal 5'-phosphate (PLP) and pyridoxamine (PMP), which function in the catabolism of carbohydrates and proteins. PLP serves as a coenzyme in more than 100 reactions in amino acid metabolism, including aminotransferases, decarboxylases, and dehydratases. Vitamin B-6 is also used in the production of red blood cells, and is involved in the single-carbon cycle, which produces methyl groups used in the synthesis of other compounds.* By this mechanism, Vitamin B-6 promotes healthy homocysteine levels.*

Folic Acid, also known as folate, functions as a coenzyme essential to virtually all biochemical reactions that use single-carbon transfers, including purine and pyrimidine biosynthesis, generation of formate, and amino acid interconversions, including homocysteine to methionine.* Folic Acid participates in the breakdown of proteins and the formation of hemoglobin, a compound in red blood cells that transports oxygen and carbon dioxide.* Healthful diets with adequate folate may reduce a woman's risk of having a child with a brain or spinal cord birth defect.

Vitamin B-12 (Cobalamin) is a coenzyme in the single-carbon cycle, and, with Vitamin B-6 and Folate, converts homocysteine to methionine.* Vitamin B-12 is also required for maintenance of nerve sheaths, normal blood formation, and DNA synthesis and repair.*

Pantothenic acid is used for the synthesis of coenzyme A and thus is involved in many metabolic pathways, including energy metabolism.* Biotin functions as a coenzyme in carboxylation reactions, which are also useful in many functions of the body.*

CLINICAL EVIDENCE

• A study followed 370 elderly people for three years and monitored their cognitive function, along with serum levels of Vitamin B-12 and Folate. A comparable pattern was found between higher levels of these vitamins and maintenance of cognitive function. (Wang et al, 2001)
• A review in the Journal of the American Medical Association stated that most people do not consume optimal amounts of vitamins by diet alone. In fact, suboptimal intake of some vitamins, even above levels classified as deficiency, may be unhealthy and is common in the general population. The reviewers concluded that it is wise for all adults to take vitamin supplements. (Fairfield and Fletcher, 2002)

SUGGESTED DOSAGE

For adults, take one (1) tablet daily, preferably with a meal or follow the advice of your healthcare professional. As a reminder, discuss the supplements and medications you take with your healthcare providers.